The tyrosine phosphatase Shp2 in development and cancer.
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By moonlighting in the nucleus, villin regulates epithelial plasticity.Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinasesMolecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsSelective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivoFunctional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populationsLoss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome.Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuriaNew insights into signalling networks regulating breast cancer stem cells.Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signalingSrc-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis.Metabolic regulation by protein tyrosine phosphatases.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population.LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesityTherapeutic targets for neuroblastomas.SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.Immune biomarkers of anti-EGFR monoclonal antibody therapyIntegrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery.RASSF1A: Not a prototypical Ras effector.SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fatesSHP2 regulates osteoclastogenesis by promoting preosteoclast fusion.FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling.Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 InhibitorsShp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formationDeletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in miceExpression and clinical significance of tyrosine phosphatase SHP2 in thyroid carcinomaDiscovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidityPlexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytesA tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinomaAge-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection.The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migrationRole of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification.Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosisShp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestineSHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
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The tyrosine phosphatase Shp2 in development and cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The tyrosine phosphatase Shp2 in development and cancer.
@en
The tyrosine phosphatase Shp2 in development and cancer.
@nl
type
label
The tyrosine phosphatase Shp2 in development and cancer.
@en
The tyrosine phosphatase Shp2 in development and cancer.
@nl
prefLabel
The tyrosine phosphatase Shp2 in development and cancer.
@en
The tyrosine phosphatase Shp2 in development and cancer.
@nl
P2093
P1476
The tyrosine phosphatase Shp2 in development and cancer.
@en
P2093
Carmen Birchmeier
Katja S Grossmann
Marta Rosário
Walter Birchmeier
P356
10.1016/S0065-230X(10)06002-1
P577
2010-01-01T00:00:00Z