IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics - Wikidata - wikimedia - TriplyDB

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

http://www.wikidata.org/entity/Q37734751

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The evolution of genome-scale models of cancer metabolism IDH1 and IDH2 mutations in gliomas Mitochondrial metabolic remodeling in response to genetic and environmental perturbations Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells Genetic profiling of intrahepatic cholangiocarcinoma and its clinical implication in targeted therapy Epigenetic regulators and their impact on therapy in acute myeloid leukemia Functions of TET Proteins in Hematopoietic Transformation From systems to structure: bridging networks and mechanism New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Connections between TET proteins and aberrant DNA modification in cancer Isocitrate dehydrogenase mutations: new opportunities for translational research Molecular biology of gliomas: present and future challenges From fly wings to targeted cancer therapies: a centennial for notch signaling Nutrient-sensing pathways and metabolic regulation in stem cells IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.New IDH1 mutant inhibitors for treatment of acute myeloid leukemia An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.Emerging concepts of epigenetic dysregulation in hematological malignancies Epigenetics in Cancer: A Hematological Perspective Metabolic consequences of oncogenic IDH mutations Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Mitochondria and cancer Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches Metabolic requirements for the maintenance of self-renewing stem cells.Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.Metabolic regulation of stem cell function.The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.Oncometabolites: linking altered metabolism with cancer.Genomic insights into cancer-associated aberrant CpG island hypermethylation Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.Glial progenitors as targets for transformation in glioma.

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

http://www.wikidata.org/entity/Q37734751

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on August 2012

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

IDH1

@nl

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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type

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IDH1

@nl

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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prefLabel

IDH1

@nl

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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Andrew Wakeham

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Anne Brüstle

http://www.w3.org/2001/XMLSchema#string

Annick You-Ten

http://www.w3.org/2001/XMLSchema#string

Ari Melnick

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Carl Virtanen

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Christiane B Knobbe

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Dirk Brenner

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Dwayne L Barber

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Evan F Lind

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Isaac S Harris

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P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

The UCSC Genome Browser database: update 2011

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

An integrated genomic analysis of human glioblastoma multiforme

Statistical significance for genomewide studies

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients.

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scholarly article

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10.1038/NATURE11323

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7413

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488

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Guido Reifenberger

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2012-08-01T00:00:00Z

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22763442

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