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Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

http://www.wikidata.org/entity/Q37764802

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An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes Identification and characterization of new family members in the tautomerase superfamily: analysis and implications F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetales Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis.Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin Neuropeptides and the microbiota-gut-brain axis Mutasynthesis of a potent anticancer sibiromycin analogue From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).Advances in the development of hybrid anticancer drugs.A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.Unravelling the biology of SCLC: implications for therapy.New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond?The Toxin-Producing Pathobiont Klebsiella oxytoca Is Not Associated with Flares of Inflammatory Bowel Diseases.4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage Sequence analysis of porothramycin biosynthetic gene cluster.A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis.An Activator of an Adenylation Domain Revealed by Activity but Not Sequence Homology.Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid.Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline.The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis.Novel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines.

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Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

http://www.wikidata.org/entity/Q37764802

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 June 2010

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

@en

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines.

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type

label

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

@en

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines.

@nl

prefLabel

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

@en

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines.

@nl

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Medicinal Research Reviews

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Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

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Barbara Gerratana

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The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad

Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization

Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex

Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity

Isolation and identification of 3-propylidene-delta 1-pyrroline-5-carboxylic acid, a biosynthetic precursor of lincomycin

Bioconversion of tyrosine into the propylhygric acid moity of lincomycin

Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11

Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum

Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes

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254-293

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10.1002/MED.20212

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2

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