Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns.
about
Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism.High-throughput glycosylation analysis of therapeutic immunoglobulin G by capillary gel electrophoresis using a DNA analyzerTowards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylationAnalysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody.Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles--part 1: separation-based methodsQuality assessment for clinical proteomics.Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach.Tailoring recombinant protein quality by rational media design.An automated data-driven DSP development approach for glycoproteins from yeast.Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review.A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions.State-of-the-art technologies for rapid and high-throughput sample preparation and analysis of N-glycans from antibodies.Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality.Glycosylation of monoclonal antibody products: Current status and future prospects.Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors.Diversity in host clone performance within a Chinese hamster ovary cell line.Impact of cell culture on recombinant monoclonal antibody product heterogeneity.What can mathematical modelling say about CHO metabolism and protein glycosylation?Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation.A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation.Characterizing the effect of multiple Fc glycan attributes on the effector functions and FcγRIIIa receptor binding activity of an IgG1 antibody.Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture ComponentsOnline enzymatic sequencing of glycans from Trastuzumab by phospholipid-assisted capillary electrophoresis.An improved model framework linking the extracellular environment to antibody glycosylation.Metabolite profiling of CHO cells with different growth characteristics.Trends in Upstream and Downstream Process Development for Antibody Manufacturing.Optimization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate Bayesian approach.Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling.Modulation of mAb quality attributes using microliter scale fed-batch cultures.Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein.
P2860
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P2860
Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Towards the implementation of ...... esired glycosylation patterns.
@en
Towards the implementation of ...... esired glycosylation patterns.
@nl
type
label
Towards the implementation of ...... esired glycosylation patterns.
@en
Towards the implementation of ...... esired glycosylation patterns.
@nl
prefLabel
Towards the implementation of ...... esired glycosylation patterns.
@en
Towards the implementation of ...... esired glycosylation patterns.
@nl
P2860
P356
P1476
Towards the implementation of ...... esired glycosylation patterns.
@en
P2093
Judit M Nagy
P2860
P304
P356
10.1002/BTPR.470
P577
2010-11-01T00:00:00Z