about
Modeling amino acid metabolism in mammalian cells-toward the development of a model library.Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylationTowards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns.The role of ER stress-induced apoptosis in neurodegeneration.Analysis of the landscape of biologically-derived pharmaceuticals in Europe: dominant production systems, molecule types on the rise and approval trends.A systems biology approach to optimising hosts for industrial protein production.Genetically-encoded biosensors for monitoring cellular stress in bioprocessing.Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation.A framework for the systematic design of fed-batch strategies in mammalian cell culture.Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity.A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus.How does mild hypothermia affect monoclonal antibody glycosylation?Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach.Systematic methodology for the development of mathematical models for biological processes.Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation.Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.Dynamic profiling of amino acid transport and metabolism in Chinese hamster ovary cell culture.Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody-producing cell cultures.Genome-based kinetic modeling of cytosolic glucose metabolism in industrially relevant cell lines: Saccharomyces cerevisiae and Chinese hamster ovary cells.A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture.An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells.Host cell protein removal from biopharmaceutical preparations: Towards the implementation of quality by designMetabolic characterization and modeling of fermentation process of an engineered Geobacillus thermoglucosidasius strain for bioethanol production with gas strippingGlobal sensitivity analysis and meta-modeling of an ethanol production processDevelopment and design of bio-pharmaceutical processesModel-based optimization of antibody galactosylation in CHO cell culture
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Cleo Kontoravdi
@ast
Cleo Kontoravdi
@en
Cleo Kontoravdi
@es
Cleo Kontoravdi
@sl
type
label
Cleo Kontoravdi
@ast
Cleo Kontoravdi
@en
Cleo Kontoravdi
@es
Cleo Kontoravdi
@sl
prefLabel
Cleo Kontoravdi
@ast
Cleo Kontoravdi
@en
Cleo Kontoravdi
@es
Cleo Kontoravdi
@sl
P106
P1153
9338385000
P21
P31
P496
0000-0003-0213-4830