Coagulation factor XI as a novel target for antithrombotic treatment.
about
Nonsense-mediated mRNA decay among coagulation factor genesFactor XI as a target for antithrombotic therapyCreating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug designDesigning allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIaMurine models in the evaluation of heparan sulfate-based anticoagulants.Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants.The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis.PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsisFactor XIa inhibitors: A review of the patent literature.Evidence for factor IX-independent roles for factor XIa in blood coagulation.Factor XII inhibition reduces thrombus formation in a primate thrombosis model.Investigational anticoagulants for hematological conditions: a new generation of therapies.Small molecule inhibitors in the treatment of cerebral ischemia.Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin.Oligonucleotides targeting coagulation factor mRNAs: use in thrombosis and hemophilia research and therapy.Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation.Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women.Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.Targeting factor XI to prevent thrombosisCoagulation factors, anticoagulant proteins, and plasminogen in Mexican older adults.First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.New players in haemostasis and thrombosis.Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factorsFragment-Based Lead Generation of 5-Phenyl-1-pyrazole-3-carboxamide Derivatives as Leads for Potent Factor Xia Inhibitors
P2860
Q26747371-6666BCE7-5078-484A-AED6-75558BCC8E79Q26865486-B5A8EB45-B165-4C0D-AC7B-803D64871C32Q28543133-46CA7EDD-E278-464D-9B05-2B2C75827CA3Q34435690-855BA2BE-FB6F-41EB-9BA7-710887261262Q34547334-B3272F19-A8A4-4FD4-9F49-0D4358F1C0A7Q35193770-F1B3CC6E-A056-421F-A23F-F4E9CD2736B2Q35920828-FE55743B-F2B6-42E7-BA31-F7F7E8DABE4AQ36106323-F36994B3-7A5A-4607-AB9F-52EE5AC6D53EQ36998581-3B2ECB6E-72BE-4729-A793-50A41EB8DDBDQ37087491-3C975B2B-D981-41B3-922C-E435EA02A340Q37626463-79409124-3B8D-4A71-8D58-86154EB6AEEFQ37636983-7E8E4F0D-6D6D-4DF8-BC04-8DF457CA47B0Q38123237-37C75C63-0D5A-46ED-9B33-FE4506E683E4Q38184644-AB95E48F-1FFE-4F45-BA4D-D754882094F0Q39117235-61CD49B8-F48C-42C3-96D5-838A9FB9CEA5Q39175404-4E787056-7675-4C44-BEA6-2DEF70B7ACEFQ40001157-A63F7D28-86F7-47E3-AB8B-CDA1CE0E873FQ40732678-269D683C-7283-490F-BAA0-A4A6DDD1E6A9Q40753182-8E2E3E42-C064-46B4-BB35-7CA515892396Q42792418-6782516F-A9F8-4751-8F40-CDA82E83F78CQ47949852-66C1C516-A922-48AA-A379-A62318A95C48Q48217479-DC9275BA-4308-4DAF-A933-69FD95B82BE4Q55652396-8E7C6779-6E19-465B-A4DA-D3AAE545CD6AQ57303396-F55C51F1-6D9A-4572-9ACC-D692F23A48C0Q58692787-F45D2A2B-E624-4E2D-BF7B-775D2E4DC810
P2860
Coagulation factor XI as a novel target for antithrombotic treatment.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Coagulation factor XI as a novel target for antithrombotic treatment.
@en
Coagulation factor XI as a novel target for antithrombotic treatment.
@nl
type
label
Coagulation factor XI as a novel target for antithrombotic treatment.
@en
Coagulation factor XI as a novel target for antithrombotic treatment.
@nl
prefLabel
Coagulation factor XI as a novel target for antithrombotic treatment.
@en
Coagulation factor XI as a novel target for antithrombotic treatment.
@nl
P2093
P2860
P1476
Coagulation factor XI as a novel target for antithrombotic treatment
@en
P2093
P2860
P304
P356
10.1111/J.1538-7836.2010.04031.X
P50
P577
2010-11-01T00:00:00Z