Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.

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http://www.wikidata.org/entity/Q37781814
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseAlzPlatform: an Alzheimer's disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research.A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.BACE1 as a potential biomarker for Alzheimer's diseaseOPTIMIZING DIAGNOSIS AND MANANGEMENT IN MILD-TO-MODERATE ALZHEIMER'S DISEASE.β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's diseaseCan BACE1 inhibition mitigate early axonal pathology in neurological diseases?Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.Alzheimers disease: review of emerging treatment role for intravenous immunoglobulins.Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease.Silencing of amyloid precursor protein expression using a new engineered delta ribozyme.Investigation of flap flexibility of β-secretase using molecular dynamic simulations.Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells.Alzheimer's disease hypothesis and related therapies.
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Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.

Item
http://www.wikidata.org/entity/Q37781814
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@en
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@nl
type
label
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@en
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@nl
prefLabel
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@en
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Is BACE1 a suitable therapeuti ...... ategies and future directions.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921