Targeting hypoxic cells through the DNA damage response.
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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapySwitching off malignant mesothelioma: exploiting the hypoxic microenvironmentStemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment.ATM signalling and cancer.Targeting lung cancer through inhibition of checkpoint kinases.BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease.Complexes of mismatched and complementary DNA with minor groove binders. Structures at nucleotide resolution via an improved hydroxyl radical cleavage methodology.Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activationTAT-ODD-p53 enhances the radiosensitivity of hypoxic breast cancer cells by inhibiting Parkin-mediated mitophagy.Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroidsMechanisms of chemoresistance in cancer stem cells.Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells.Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.Chromatin as an oxygen sensor and active player in the hypoxia response.Tumor hypoxia as a driving force in genetic instability.Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironmentCH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.Targeting radiation-resistant hypoxic tumour cells through ATR inhibitionHypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradationLRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation.Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroidsHypoxia-induced alterations of G2 checkpoint regulators.Strategies to optimize radiotherapy based on biological responses of tumor and normal tissue.EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair.N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult ratsATR/CHK1 inhibitors and cancer therapy.Challenges to DNA replication in hypoxic conditions.
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Targeting hypoxic cells through the DNA damage response.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 September 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Targeting hypoxic cells through the DNA damage response.
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Targeting hypoxic cells through the DNA damage response.
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Targeting hypoxic cells through the DNA damage response.
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Targeting hypoxic cells through the DNA damage response.
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Targeting hypoxic cells through the DNA damage response.
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Targeting hypoxic cells through the DNA damage response.
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P2093
P2860
P1476
Targeting hypoxic cells through the DNA damage response.
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P2093
Ester M Hammond
Monica Olcina
Philip S Lecane
P2860
P304
P356
10.1158/1078-0432.CCR-10-0286
P407
P577
2010-09-27T00:00:00Z