Zinc-finger nuclease based genome surgery: it's all about specificity.
about
Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyondTargeted gene disruption to cure HIVIn vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle deliveryImproved assays for determining the cytosolic access of peptides, proteins, and their mimetics.TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicityType II restriction endonucleases--a historical perspective and moreSelection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effectsTALE-PvuII fusion proteins--novel tools for gene targeting.Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition.AAV-mediated delivery of zinc finger nucleases targeting hepatitis B virus inhibits active replicationLife or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock.Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors.In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCsTALENs: a widely applicable technology for targeted genome editing.Zinc Finger Nucleases: Tailor-made for Gene TherapyApplication of cancer-associated glycoforms and glycan-binding probes to an in vitro diagnostic multivariate index assay for precise diagnoses of cancerAllogeneic blood and bone marrow cells for the treatment of severe epidermolysis bullosa: repair of the extracellular matrix.Genotoxicity of retroviral hematopoietic stem cell gene therapy.Generation of novel nucleases with extended specificity by rational and combinatorial strategies.Concise review: managing genotoxicity in the therapeutic modification of stem cells.Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.Gene-based therapies for dominantly inherited retinopathies.The Sleeping Beauty transposon system for clinical applications.Zinc finger nucleases: looking toward translation.Technological overview of iPS induction from human adult somatic cells.Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cellsTALEN gene editing takes aim on HIV.Epigenome Editing in the Brain.Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells.Compact designer TALENs for efficient genome engineering.Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases.CCR5 Gene Editing of Resting CD4(+) T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized MiceAdding fingers to an engineered zinc finger nuclease can reduce activity.A novel zinc-finger nuclease platform with a sequence-specific cleavage module.Highly efficient zinc-finger nuclease-mediated disruption of an eGFP transgene in keratinocyte stem cells without impairment of stem cell properties.
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Zinc-finger nuclease based genome surgery: it's all about specificity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Zinc-finger nuclease based genome surgery: it's all about specificity.
@en
Zinc-finger nuclease based genome surgery: it's all about specificity.
@nl
type
label
Zinc-finger nuclease based genome surgery: it's all about specificity.
@en
Zinc-finger nuclease based genome surgery: it's all about specificity.
@nl
prefLabel
Zinc-finger nuclease based genome surgery: it's all about specificity.
@en
Zinc-finger nuclease based genome surgery: it's all about specificity.
@nl
P1433
P1476
Zinc-finger nuclease based genome surgery: it's all about specificity.
@en
P2093
Eva-Maria Händel
P356
10.2174/156652311794520120
P407
P577
2011-02-01T00:00:00Z