Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders.
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Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative DiseasesPET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primatesDecreased zinc in the development and progression of malignancy: an important common relationship and potential for prevention and treatment of carcinomas.Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activationPredicting adverse drug reactions using publicly available PubChem BioAssay dataClioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathicaTools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.Interrelationships of undernutrition and neurotoxicity: food for thought and research attention.The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus.Clawing back: broadening the notion of metal chelators in medicineThe antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.Zinc and the aging brainIdentification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity.Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease.Zinc and its effects on oxidative stress in Alzheimer's disease.Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer.Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules.Antioxidant and Metal Chelation-Based Therapies in the Treatment of Prion Disease.Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol.Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.The cytotoxic role of RREB1, ZIP3 zinc transporter, and zinc in human pancreatic adenocarcinoma.The gut: a triggering place for autism - possibilities and challenges.Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation.Time-Resolved Pharmacological Studies using Automated, On-line Monitoring of Five Parallel Suspension CulturesNovel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer's Disease.Crystal structure of (pyridine-κN)bis(quinolin-2-olato-κ(2) N,O)copper(II) monohydrate.Evidence that Human Prostate Cancer is a ZIP1-Deficient Malignancy that could be Effectively Treated with a Zinc Ionophore (Clioquinol) Approach.A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy.Effects of clioquinol on the scuticociliatosis-causing protozoan Miamiensis avidus in olive flounder Paralichthys olivaceus.Development of a copper-clioquinol formulation suitable for intravenous use.Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities.Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application.Inhibition of copper-mediated aggregation of human γD-crystallin by Schiff bases.The Oral Iron Chelator, Deferasirox, Reverses the Age-Dependent Alterations in Iron and Amyloid-β Homeostasis in Rat Brain: Implications in the Therapy of Alzheimer's Disease.Amikacin: Uses, Resistance, and Prospects for Inhibition.Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease.Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases.
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P2860
Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 December 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@en
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@nl
type
label
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@en
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@nl
prefLabel
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@en
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@nl
P2860
P1476
Clioquinol: review of its mech ...... n neurodegenerative disorders.
@en
P2093
Silvio R Bareggi
Umberto Cornelli
P2860
P356
10.1111/J.1755-5949.2010.00231.X
P577
2010-12-27T00:00:00Z