AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
about
Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors.Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth.Translation of molecular pathways into clinical trials of neuroendocrine tumors.Anti-angiogenic drugs currently in Phase II clinical trials for gynecological cancer treatment.Targeting angiogenesis in renal cell carcinoma.Efficacy of trebananib (AMG 386) in treating epithelial ovarian cancer.Fcγ1 fragment of IgG1 as a powerful affinity tag in recombinant Fc-fusion proteins: immunological, biochemical and therapeutic properties.Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.Peptibodies: An elegant solution for a long-standing problem.Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma.Computational Design of Antiangiogenic Peptibody by Fusing Human IgG1 Fc Fragment and HRH Peptide: Structural Modeling, Energetic Analysis, and Dynamics Simulation of Its Binding Potency to VEGF Receptor.
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AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 January 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
@en
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
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type
label
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
@en
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
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prefLabel
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
@en
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
@nl
P2860
P1476
AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer.
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P2093
Ewan Jd Robson
Prafull Ghatage
P2860
P304
P356
10.1517/13543784.2011.549125
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P577
2011-01-06T00:00:00Z