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Leukemia stem cells and microenvironment: biology and therapeutic targeting.

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

http://www.wikidata.org/entity/Q37827279

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Targeting the leukemia-stroma interaction in acute myeloid leukemia: rationale and latest evidence Humanized hemato-lymphoid system mice Cancer stem cell targeted therapy: progress amid controversies.Advances in understanding the leukaemia microenvironment A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management.Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?Fibroblast activation protein α in tumor microenvironment: recent progression and implications (review)CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells Survival regulation of leukemia stem cells Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors.Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment Wnt-responsive cancer stem cells are located close to distorted blood vessels and not in hypoxic regions in a p53-null mouse model of human breast cancer.Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia.Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.Cellular distribution studies of the nitric oxide-generating antineoplastic prodrug O(2) -(2,4-dinitrophenyl)1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate formulated in Pluronic P123 micelles.Number of glioma polyploid giant cancer cells (PGCCs) associated with vasculogenic mimicry formation and tumor grade in human glioma.CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth.Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Tyrosine kinase inhibition: a therapeutic target for the management of chronic-phase chronic myeloid leukemia.Chimeric antigen receptor T cell therapy in AML: How close are we?Peroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells.A Phase 2 study of bortezomib combined with either idarubicin/cytarabine or cytarabine/etoposide in children with relapsed, refractory or secondary acute myeloid leukemia: a report from the Children's Oncology Group The N-terminal CEBPA mutant in acute myeloid leukemia impairs CXCR4 expression Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway.Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic Proteomic profiling identifies distinct protein patterns in acute myelogenous leukemia CD34+CD38- stem-like cells.Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia.The intricate role of CXCR4 in cancer.iTRAQ-based proteomic analysis of polyploid giant cancer cells and budding progeny cells reveals several distinct pathways for ovarian cancer development.Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia Clinical and prognostic implications of Roundabout 4 (robo4) in adult patients with acute myeloid leukemia.Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells.

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Leukemia stem cells and microenvironment: biology and therapeutic targeting.

http://www.wikidata.org/entity/Q37827279

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 January 2011

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@en

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@nl

type

label

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@en

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@nl

prefLabel

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@en

Leukemia stem cells and microenvironment: biology and therapeutic targeting.

@nl

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JCO.2010.31.0904

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Journal of Clinical Oncology

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Leukemia stem cells and microenvironment: biology and therapeutic targeting.

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Craig T Jordan

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Marina Y Konopleva

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P2860

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Wnt/beta-catenin signaling: components, mechanisms, and diseases

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

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591-599

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scholarly article

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10.1200/JCO.2010.31.0904

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5

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29

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2011-01-10T00:00:00Z

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21220598

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4874213

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