The state of the art in anti-malarial drug discovery and development.
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Global phenotypic screening for antimalarialsAn evolutionary perspective on the kinome of malaria parasitesCholine analogues in malaria chemotherapyDesigning the next generation of medicines for malaria control and eradicationNew N-Acetyltransferase Fold in the Structure and Mechanism of the Phosphonate Biosynthetic Enzyme FrbFMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetKilling the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivaxThe open access malaria box: a drug discovery catalyst for neglected diseasesA new in vivo screening paradigm to accelerate antimalarial drug discoveryPyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine HybridsDesign, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserineSynthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives.Evaluation of aminohydantoins as a novel class of antimalarial agents.Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporinHaemozoin induces early cytokine-mediated lysozyme release from human monocytes through p38 MAPK- and NF-kappaB-dependent mechanismsAntimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.Malaria biology and disease pathogenesis: insights for new treatments.Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1.4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation.Drugs for malaria: something old, something new, something borrowed.Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasitesNowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.Novel potent metallocenes against liver stage malaria.Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases.Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties.Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenaseSustainable malaria control: transdisciplinary approaches for translational applications.1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsTetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial ActivityA physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs.Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasitesAntimalarial drug discovery - the path towards eradication.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Small molecule anti-malarial patents: a review (January 2010-June 2011).Terpenoids: natural products for cancer therapy.
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P2860
The state of the art in anti-malarial drug discovery and development.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The state of the art in anti-malarial drug discovery and development.
@en
The state of the art in anti-malarial drug discovery and development.
@nl
type
label
The state of the art in anti-malarial drug discovery and development.
@en
The state of the art in anti-malarial drug discovery and development.
@nl
prefLabel
The state of the art in anti-malarial drug discovery and development.
@en
The state of the art in anti-malarial drug discovery and development.
@nl
P50
P1476
The state of the art in anti-malarial drug discovery and development.
@en
P304
P356
10.2174/156802611795429194
P577
2011-01-01T00:00:00Z