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The open access malaria box: a drug discovery catalyst for neglected diseases

The open access malaria box: a drug discovery catalyst for neglected diseases

http://www.wikidata.org/entity/Q28533977

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The European Bioinformatics Institute's data resources 2014 The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs The ChEMBL bioactivity database: an update Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites Characterization and redox regulation of Plasmodium falciparum methionine adenosyltransferase Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5 Muddled mechanisms: recent progress towards antimalarial target identification Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni New developments in anti-malarial target candidate and product profiles Orally active antischistosomal early leads identified from the open access malaria box Finding new collaboration models for enabling neglected tropical disease drug discovery Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity Identification of MMV Malaria Box inhibitors of Perkinsus marinus using an ATP-based bioluminescence assay Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis Bilayer Effects of Antimalarial Compounds A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases The ChEMBL database in 2017 Activity, assay and target data curation and quality in the ChEMBL database Open source drug discovery - a limited tutorial Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria Is Open Science the Future of Drug Development?Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis Hidden reservoir of resistant parasites: the missing link in the elimination of falciparum malaria.Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica Diverse chemotypes disrupt ion homeostasis in the Malaria parasite.Prioritization of active antimalarials using structural interaction profile of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR)-triclosan derivatives.Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids.Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box.Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box Against Intracellular Leishmania major Amastigotes Open Access Could Transform Drug Discovery: A Case Study of JQ1.

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The open access malaria box: a drug discovery catalyst for neglected diseases

http://www.wikidata.org/entity/Q28533977

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The open access malaria box: a drug discovery catalyst for neglected diseases

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The open access malaria box: a drug discovery catalyst for neglected diseases

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The open access malaria box: a drug discovery catalyst for neglected diseases

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The open access malaria box: a drug discovery catalyst for neglected diseases

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Paul Kowalczyk

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Paul Willis

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Simon McDonald

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Thomas Spangenberg

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Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

Thousands of chemical starting points for antimalarial lead identification

Privileged scaffolds for library design and drug discovery

Genomic-scale prioritization of drug targets: the TDR Targets database

Global phenotypic screening for antimalarials

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

ChEMBL: a large-scale bioactivity database for drug discovery

Phenotypic screens, chemical genomics, and antimalarial lead discovery

The next opportunity in anti-malaria drug discovery: the liver stage

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Timothy N C Wells

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open-source drug discovery

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