Inhibitors of MDM2 and MDMX: a structural perspective. - Wikidata - wikimedia - TriplyDB

Inhibitors of MDM2 and MDMX: a structural perspective.

Inhibitors of MDM2 and MDMX: a structural perspective.

http://www.wikidata.org/entity/Q37855826

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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.MDM2 oligomers: antagonizers of the guardian of the genome.Association between murine double minute 2 T309G polymorphism and risk of liver cancer.Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation Molecular dynamic simulation insights into the normal state and restoration of p53 function.Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53-MDM2 Interaction Useful in Targeted Cancer Therapy.Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.

P2860

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P2860

Inhibitors of MDM2 and MDMX: a structural perspective.

http://www.wikidata.org/entity/Q37855826

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on September 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Inhibitors of MDM2 and MDMX: a structural perspective.

@en

Inhibitors of MDM2 and MDMX: a structural perspective.

@nl

type

label

Inhibitors of MDM2 and MDMX: a structural perspective.

@en

Inhibitors of MDM2 and MDMX: a structural perspective.

@nl

prefLabel

Inhibitors of MDM2 and MDMX: a structural perspective.

@en

Inhibitors of MDM2 and MDMX: a structural perspective.

@nl

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P1433

Future Medicinal Chemistry

P1476

Inhibitors of MDM2 and MDMX: a structural perspective

@en

P2093

Christiane Riedinger

http://www.w3.org/2001/XMLSchema#string

P2860

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

The Protein Data Bank

P304

1075-1094

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P31

scholarly article

P356

10.4155/FMC.09.75

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P433

6

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P478

1

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P50

James M. McDonnell

P577

2009-09-01T00:00:00Z

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P698

21425995

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