Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionRole of solute carriers in response to anticancer drugsThe first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio).Membrane transporters as mediators of Cisplatin effects and side effects.The Concise Guide to PHARMACOLOGY 2013/14: transporters.Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modelingBile formation and secretion.Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.Verapamil decreases the glucose-lowering effect of metformin in healthy volunteersInteraction of innovative small molecule drugs used for cancer therapy with drug transporters.Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory MechanismsThe multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubulesThe Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs.Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.Species differences in drug transporters and implications for translating preclinical findings to humans.Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.Emerging transporters of clinical importance: an update from the International Transporter Consortium.In vitro methods to support transporter evaluation in drug discovery and development.Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism.Stereoselectivity of chiral drug transport: a focus on enantiomer-transporter interaction.Raltegravir has a low propensity to cause clinical drug interactions through inhibition of major drug transporters: an in vitro evaluation.The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation.The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.Loops and layers of post-translational modifications of drug transporters.Evaluation and Quantitative Prediction of Renal Transporter-Mediated Drug-Drug Interactions.Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2.Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat.Urinary Dopamine as a Potential Index of the Transport Activity of Multidrug and Toxin Extrusion in the Kidney.Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury.Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.Transporters are an under-developed therapeutic target. Discuss.LUCS (Light-Up Cell System), a universal high throughput assay for homeostasis evaluation in live cells.Involvement of organic cation transporters in the clearance and milk secretion of thiamine in mice.On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent.Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy.
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Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Importance of the multidrug an ...... odynamics and pharmacogenomics
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Importance of the multidrug an ...... dynamics and pharmacogenomics.
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Importance of the multidrug an ...... odynamics and pharmacogenomics
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Importance of the multidrug an ...... dynamics and pharmacogenomics.
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Importance of the multidrug an ...... odynamics and pharmacogenomics
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Importance of the multidrug an ...... dynamics and pharmacogenomics.
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P1476
Importance of the multidrug an ...... odynamics and pharmacogenomics
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P2093
Atsushi Yonezawa
Ken-ichi Inui
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P304
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10.1111/J.1476-5381.2011.01394.X
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P577
2011-12-01T00:00:00Z