Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.
about
DNA damage and repair in plants - from models to cropsAlkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation- interactionsBiochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated VariantsInfluence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass SpectrometryStructure elucidation of DNA-protein crosslinks by using reductive desulfurization and liquid chromatography-tandem mass spectrometry.Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase.Engineering the elongation factor Tu for efficient selenoprotein synthesis.Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA.Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in LungChemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo.Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable proteinCooperative cluster formation, DNA bending and base-flipping by O6-alkylguanine-DNA alkyltransferase.Lesion-specific DNA-binding and repair activities of human O⁶-alkylguanine DNA alkyltransferase.Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanismsDNA-Protein Cross-Links: Formation, Structural Identities, and Biological OutcomesNF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug.Balancing repair and tolerance of DNA damage caused by alkylating agentsTherapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation.Expression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue.Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.Role of aldehydes in the toxic and mutagenic effects of nitrosamines.Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction.DNA repair by reversal of DNA damage.Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.Gold-Coated Superparamagnetic Nanoparticles for Single Methyl Discrimination in DNA Aptamers.O(6) -alkylguanine-DNA alkyltransferase-mediated repair of O(4) -alkylated 2'-deoxyuridines.Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1.Synthesis of building blocks and oligonucleotides containing {T}O4-alkylene-O4{T} interstrand cross-links.The potential of combi-molecules with DNA-damaging function as anticancer agents.DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.Mass Spectrometry-Based Tools to Characterize DNA-Protein Cross-Linking by Bis-Electrophiles.Mechanisms of DNA damage, repair, and mutagenesis.Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU.A novel thermostable protein-tag: optimization of the Sulfolobus solfataricus DNA- alkyl-transferase by protein engineering.Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.O(6)-methylguanine-DNA methyltransferase as a prognostic and predictive marker for basal-like breast cancer treated with cyclophosphamide-based chemotherapy.Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.
P2860
Q26777937-16AFB8DD-E2E3-430C-8E51-3F397E2BF99AQ27674815-BC93C651-EC2C-4859-80DF-0396631A0152Q27677244-7F0FEBDF-888B-418B-8725-1A0A5C717BF5Q28544849-ED02EABE-0B48-4FCC-A837-C94CBB7D7A03Q33667052-D6732884-5C5D-4F6C-94E2-73FE3DBF82C2Q33954253-01316309-0B14-40A2-8B13-97639D459069Q34115421-772666B2-4E88-48F8-B87C-1597188ECCD2Q34115496-95D1B5F1-2301-4A34-AE57-B708A3B31481Q35566644-857D9F14-B787-4EB2-986E-9D7233AC7AB3Q35920638-3171DE96-E25D-4137-8FE2-52B2C9DFFD1AQ35920833-03983674-9355-4745-863E-1DEB11B78CC8Q35965268-71B79513-6977-4123-A36B-100055C7B3ACQ36160611-E9A41651-0816-4594-BF30-453D4296C561Q36280616-E1E07C21-EB48-4BE0-8F61-65CF7851674EQ36305675-872685D2-9E5E-462A-9B2F-1A871BBB8E48Q36413288-F24A8204-E0C0-494F-8D6F-57808D3A1CEDQ36440587-019E9920-81A4-4B6C-A815-C490044D0E41Q36552658-E3E7E3D4-F813-4A91-AF99-0004894AE798Q36651488-24518FEF-5BE4-433F-B5EC-07903CFEB0D4Q36738925-C6A53F67-F1B3-48B2-A02E-D9846DCD54D9Q37087445-39600E66-3778-4648-8147-558B0F3F6FF8Q37112479-CDCAA522-7DD8-42AD-91C6-738547BC5005Q37330085-C87DD271-BA13-41D7-9F39-F50EE8E3ED8DQ37686082-5276F684-5F6B-47CE-BF99-34873D6EB358Q38071280-9156C6F7-7F63-48DE-A689-4D1760EECB5EQ38237859-39DF286E-ACA9-4D6F-9132-73D397518474Q38295161-DF1198D4-7D50-4D79-A0F1-57C54D7C2157Q38305305-5A74F534-9C1F-4704-B134-C4EA6536EF6DQ38320854-52F58BE5-8F1F-47B1-8A23-F322CBFF58AEQ38336090-746219E9-6962-4383-BF44-7A056AC41C35Q38713528-E5E9E1BE-EE0C-4325-9758-184816222F52Q38735518-1B97AF2C-AF4B-4184-BE23-77BB4B0A6FFAQ39027144-1C1E998C-707C-4C58-AAF0-288732A9F801Q39062118-D8A22A85-B286-44E2-994D-2A4C301BC271Q39293345-661E9E01-F6D6-45E2-B0E1-1D5374E6143CQ40336092-51BB750D-6838-4AC1-BACA-E702623A060CQ40395401-2DDBB8A4-5B6C-4CBB-BDE8-F9F3FD050F4DQ40422737-233F60D7-1822-4CC6-829D-8DAF9A2D822BQ40451570-7DDCC8E6-12D0-41B7-A2C8-C55FE4703736Q40680395-4ED48A00-AD36-4B7D-86BA-17F7548F555E
P2860
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 28 April 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@en
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@nl
type
label
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@en
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@nl
prefLabel
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@en
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@nl
P2860
P356
P1476
Multifaceted roles of alkyltra ...... motherapy, and research tools.
@en
P2093
Anthony E Pegg
P2860
P304
P356
10.1021/TX200031Q
P577
2011-04-28T00:00:00Z