Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.
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Stem Cell Modeling of Core Binding Factor Acute Myeloid LeukemiaAbrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22).The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.Overexpression and knockout of miR-126 both promote leukemogenesisUBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Transcription factor RUNX1 promotes survival of acute myeloid leukemia cellsCharacteristics of hematologic malignancies with coexisting t(9;22) and inv(16) chromosomal abnormalities.JAK inhibitors suppress t(8;21) fusion protein-induced leukemia.Acute lymphoblastic leukemia and developmental biology: a crucial interrelationshipNew agents for acute myeloid leukemia: is it time for targeted therapies?Posttranslational modifications of RUNX1 as potential anticancer targets.Characterization of Purine-Rich Element Binding Protein B as a Novel Biomarker in Acute Myelogenous Leukemia Prognostication.The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia.Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations.Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemia.Fadd and Skp2 are possible downstream targets of RUNX1-EVI1.MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.MiR-221-regulated KIT level by wild type or leukemia mutant RUNX1: a determinant of single myeloblast fate decisions that - collectively - drives or hinders granulopoiesis.Domain retention in transcription factor fusion genes and its biological and clinical implications: a pan-cancer study.A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.Outcomes of Patients With Relapsed Core Binding Factor-Positive Acute Myeloid Leukemia.RUNX1-ETO Leukemia.Clinical and prognostic significance of eosinophilia and inv(16)/t(16;16) in pediatric acute myelomonocytic leukemia (AML-M4).Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21).
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Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 May 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
@cs
name
Molecular pathogenesis of core ...... nowledge and future prospects.
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Molecular pathogenesis of core ...... nowledge and future prospects.
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type
label
Molecular pathogenesis of core ...... nowledge and future prospects.
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Molecular pathogenesis of core ...... nowledge and future prospects.
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prefLabel
Molecular pathogenesis of core ...... nowledge and future prospects.
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Molecular pathogenesis of core ...... nowledge and future prospects.
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P2860
P1476
Molecular pathogenesis of core ...... nowledge and future prospects.
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P2093
James C Mulloy
Susumu Goyama
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P2888
P304
P356
10.1007/S12185-011-0858-Z
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2011-05-03T00:00:00Z