Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
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A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffoldRibonucleotide reductase modularity: Atypical duplication of the ATP-cone domain in Pseudomonas aeruginosaA novel clade of unique eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasitesIn vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactionsThe structural basis for the allosteric regulation of ribonucleotide reductase.Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp.Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer.Nucleotide parasitism by Simkania negevensis (Chlamydiae).Chlamydial ribonucleotide reductase: tyrosyl radical function in catalysis replaced by the FeIII-FeIV clusterCyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins.Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis.Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo.Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance.A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase.Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis.Formation and function of the Manganese(IV)/Iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductaseThe active form of Chlamydia trachomatis ribonucleotide reductase R2 protein contains a heterodinuclear Mn(IV)/Fe(III) cluster with S = 1 ground state.Structural analysis of the Mn(IV)/Fe(III) cofactor of Chlamydia trachomatis ribonucleotide reductase by extended X-ray absorption fine structure spectroscopy and density functional theory calculations.Radical-translocation intermediates and hurdling of pathway defects in "super-oxidized" (Mn(IV)/Fe(IV)) Chlamydia trachomatis ribonucleotide reductase.Metal use in ribonucleotide reductase R2, di-iron, di-manganese and heterodinuclear--an intricate bioinorganic workaround to use different metals for the same reaction.Geometrical properties of the manganese(iv)/iron(iii) cofactor of Chlamydia trachomatis ribonucleotide reductase unveiled by simulations of XAS spectra.Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.CT406 encodes a chlamydial ortholog of NrdR, a repressor of ribonucleotide reductase.Oxygen cleavage with manganese and iron in ribonucleotide reductase from Chlamydia trachomatis.Redox intermediates of the Mn-Fe Site in subunit R2 of Chlamydia trachomatis ribonucleotide reductase: an X-ray absorption and EPR study.High catalytic activity achieved with a mixed manganese-iron site in protein R2 of Chlamydia ribonucleotide reductase.DNA building blocks: keeping control of manufacture.Assembly of nonheme Mn/Fe active sites in heterodinuclear metalloproteinsManganese, the stress reliever.Diversity in Overall Activity Regulation of Ribonucleotide Reductase.
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P2860
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2000
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@en
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@nl
type
label
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@en
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@nl
prefLabel
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@en
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@nl
P2093
P2860
P356
P1476
Cloning and characterization of ribonucleotide reductase from Chlamydia trachomatis.
@en
P2093
Iliffe-Lee ER
McClarty G
P2860
P304
38111-38119
P356
10.1074/JBC.M006367200
P407
P577
2000-12-01T00:00:00Z