Is telomerase a viable target in cancer? - Wikidata - wikimedia - TriplyDB

Is telomerase a viable target in cancer?

Is telomerase a viable target in cancer?

http://www.wikidata.org/entity/Q37908470

about

The telomere syndromes Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies Telomere biology: Rationale for diagnostics and therapeutics in cancer Progress in structural studies of telomerase Telomerase as a Cancer Target. Development of New Molecules Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.Telomerase and hTERT: can they serve as markers for gastric cancer diagnosis?Telomere Biology-Insights into an Intriguing Phenomenon.Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Diverse modes of genomic alteration in hepatocellular carcinoma A minimal connected network of transcription factors regulated in human tumors and its application to the quest for universal cancer biomarkers Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia A small molecule inhibitor of Pot1 binding to telomeric DNA.Telomere maintenance mechanisms in cancer: clinical implications Role of telomeres and telomerase in cancer Optimization of a gene electrotransfer procedure for efficient intradermal immunization with an hTERT-based DNA vaccine in mice Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study.Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.Conditional Knockout of Telomerase Reverse Transcriptase in Mesenchymal Cells Impairs Mouse Pulmonary Fibrosis.Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage DNA helicases involved in DNA repair and their roles in cancer Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.The correlation between telomerase activity and Bax/Bcl-2 ratio in valproic acid-treated MCF-7 breast cancer cell line Multi-Modal Imaging in a Mouse Model of Orthotopic Lung Cancer Telomerase as a useful target in cancer fighting-the breast cancer case.Role of Telomeres and Telomerase in Aging and Cancer.Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells.Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner.Genistein suppresses the proliferation of telomerase-negative cells.Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.Telomerase-independent paths to immortality in predictable cancer subtypes.Fluorescent probes for G-quadruplex structures.Portrait of replication stress viewed from telomeres.Breast cancer immunotherapy: monoclonal antibodies and peptide-based vaccines.Telomerase promoter mutations in cancer: an emerging molecular biomarker?Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells A combination of the telomerase inhibitor, BIBR1532, and paclitaxel synergistically inhibit cell proliferation in breast cancer cell lines.The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line.

P2860

Q24632444-0DB145EA-F1A0-4425-BC67-320DA7875788 Q26744271-B496C0AA-AFDF-4F22-94BB-0913286E39F5 Q26796323-3E7717BB-440D-4992-8AAD-33F28093EECE Q27024292-FBE986F0-4EC1-4D6A-8653-FF1FE9C32E6C Q28079188-A54E9075-B960-4890-8F87-BDE8BF2EEE43 Q30235386-F33C64CC-57F7-494A-94D3-53864E35D7B7 Q33718336-5FC64C51-4ACB-4BA2-9813-0515E6907411 Q33855946-5E5802E7-073A-43DB-A78E-B225B9AD262D Q33912756-A950CB7F-B1A6-4EED-89BB-74A9D64DD136 Q33990112-9330548D-813F-42F0-BADE-CFA60D322176 Q34306010-04A98C3F-5562-4BAC-88BD-C99F54AD5BFF Q34326409-4F23810B-13EC-4BE2-8EAB-E94981CB01FE Q34377302-8532A754-7D54-4E2D-96FA-34B3460146AF Q34414940-707BDAB7-E601-46E2-915A-61B7450F31F4 Q34426966-C14DDADE-A9AA-4F28-AB55-6438E7E70811 Q34633162-6B165541-A689-42E0-AA34-920BAC512A3D Q35184204-EDEAEAE6-C7B2-4200-A76A-9C556CA842CC Q35590195-F55D8A61-2B92-464D-A176-DD80BA003711 Q35667156-3E079813-BC94-40C9-8911-71D4DEF80A71 Q35817236-4047BF57-D42C-4431-A7AE-DA2267C78CA8 Q35837601-FA14E0C1-3601-4F36-929E-8E4D956AAB28 Q35904248-B308F331-EB20-4270-9006-A0BAC47EC76F Q35961508-B90F6347-5A90-4AF7-BC2D-B319089E0656 Q35967905-72B27DE2-2EEE-42A4-B9A2-505DB6DB78A0 Q36017178-69801018-EC48-4C23-BE96-2BE5B7683D0C Q36119987-5EEE89F4-81AF-4548-84BD-5ABEE4E640D9 Q36868580-22C793B7-6B86-4773-8DF5-59DC98580D13 Q36971261-79B23633-8ADA-49E0-B1B2-C27F7A98CB8E Q37138708-50818E7E-E1BA-4B68-AC3A-5730D3F90AB5 Q37362475-34319776-B757-4EEF-A755-7D448C709288 Q37675160-82467100-0FE0-43F6-9847-50F44D88C459 Q37733930-F6473F0F-2672-451A-A9C0-2DB0E2DAEA56 Q37982375-19176ED0-230C-4957-9000-5EC1EEAD0B1B Q38084623-CF35DF12-3764-4692-B0A3-3AFA5BEA9CBC Q38096021-45549626-4251-41F3-BB2D-DC3FD6BA1894 Q38215394-06FF7177-010F-4051-A0E5-8F0C8F1B0B7D Q38232447-B446C821-135C-4212-B074-EE7EB4395030 Q38700449-29A425B6-15AA-4584-95CC-39591503A585 Q38881802-7B84EB03-E2EA-4439-B0DB-B9217CE1BFC9 Q38925261-6CB0CAF0-3012-422E-8CA1-7BC68EC3A916

P2860

Is telomerase a viable target in cancer?

http://www.wikidata.org/entity/Q37908470

description

article científic

@ca

article scientifique

@fr

articol științific

@ro

articolo scientifico

@it

artigo científico

@gl

artigo científico

@pt

artigo científico

@pt-br

artikel ilmiah

@id

artikull shkencor

@sq

artículo científico

@es

name

Is telomerase a viable target in cancer?

@en

Is telomerase a viable target in cancer?

@nl

type

label

Is telomerase a viable target in cancer?

@en

Is telomerase a viable target in cancer?

@nl

prefLabel

Is telomerase a viable target in cancer?

@en

Is telomerase a viable target in cancer?

@nl

P1433

Q37908470-ECFDFFB8-015E-49D6-8B2C-C3A348FFA06B

P1476

Q37908470-C8A48158-5573-49BD-A67E-A29D09D2084D

P2093

Q37908470-07310D42-203B-4D80-8D51-CB4833697731

Q37908470-0917DA50-A476-43E0-86A0-1619F0A1407C

Q37908470-A1C9716D-3408-4F09-8224-DADA9E584D8F

P2860

Q37908470-00E09CDD-5784-47B3-A574-F398EE878436

Q37908470-02297098-DAD7-4C16-BB0F-49362899E2E8

Q37908470-043265A4-CF33-4A6E-B950-112B707F5BEF

Q37908470-07F82580-BE9E-4D47-9C1D-A0688DF86D9C

Q37908470-0C09DBEF-15A0-4075-A39E-B84E71DFAF20

Q37908470-0CC86A13-B0E0-4459-B0FF-0145DD58300D

Q37908470-0ED04189-7B06-46D8-A63A-6A162A1210AC

Q37908470-0F9A53AD-C1AD-41D7-90EF-AA4593295EBD

Q37908470-10F1A003-0657-4DD4-8179-1798F9FA58AC

Q37908470-129EE447-BEB2-42EA-B901-13A7B508E1E0

P304

Q37908470-D926B686-841F-48EF-B6FE-3ACF098C09F4

P31

Q37908470-ACDA9458-F8D9-412F-B017-06F9E38A356E

P356

Q37908470-675EBFD4-C733-4B89-9751-BAD489657293

P407

Q37908470-1B46D85C-0C65-42BE-BDB5-79DB0E0B2D74

P433

Q37908470-709B932A-EC6B-491A-8E8D-76AB8E8F9EAB

P478

Q37908470-6869C834-7658-4889-B663-BB483ACA29F0

P577

Q37908470-F10AC8FC-1D1C-47C7-B3CD-AF9D7B0F2766

P5875

Q37908470-EF56D2D9-DCDD-4291-A72F-19CFCC7B0425

P698

Q37908470-21B90ED7-133C-4F44-84DC-B5992B2AC8A6

P932

Q37908470-3E077CC3-F58A-45D3-BE77-898FAECF9C35

P356

J.MRFMMM.2011.07.006

P1433

Mutation Research

P1476

Is telomerase a viable target in cancer?

@en

P2093

C M Buseman

http://www.w3.org/2001/XMLSchema#string

J W Shay

http://www.w3.org/2001/XMLSchema#string

W E Wright

http://www.w3.org/2001/XMLSchema#string

P2860

First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting

Mammalian telomeres end in a large duplex loop

The Hallmarks of Cancer

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

Human telomerase and its regulation

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Human telomerase contains evolutionarily conserved catalytic and structural subunits

Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study

P304

90-97

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.MRFMMM.2011.07.006

http://www.w3.org/2001/XMLSchema#string

P407

P433

1-2

http://www.w3.org/2001/XMLSchema#string

P478

730

http://www.w3.org/2001/XMLSchema#string

P577

2011-07-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51533727

http://www.w3.org/2001/XMLSchema#string

P698

21802433

http://www.w3.org/2001/XMLSchema#string

P932

3375693

http://www.w3.org/2001/XMLSchema#string