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Drug targets from genetics: α-synuclein.

Drug targets from genetics: α-synuclein.

http://www.wikidata.org/entity/Q37916635

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Drug targets: single-cell transcriptomics hastens unbiased discovery GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.

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Drug targets from genetics: α-synuclein.

http://www.wikidata.org/entity/Q37916635

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article científic

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article scientifique

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artikel ilmiah

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Drug targets from genetics: α-synuclein.

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Drug targets from genetics: α-synuclein.

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Drug targets from genetics: α-synuclein.

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Drug targets from genetics: α-synuclein.

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prefLabel

Drug targets from genetics: α-synuclein.

@en

Drug targets from genetics: α-synuclein.

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187152711797247867

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CNS and Neurological Disorders

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Drug targets from genetics: α-synuclein.

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Karin M Danzer

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Pamela J McLean

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P2860

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

A receptor for the selective uptake and degradation of proteins by lysosomes

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

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712-723

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scholarly article

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10.2174/187152711797247867

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6

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10

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2011-09-01T00:00:00Z

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51568594

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21838671

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3364517

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