The phosphoinositide 3-kinase signaling pathway as a therapeutic target in grade IV brain tumors.
about
Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma.OSU-03012 interacts with lapatinib to kill brain cancer cellsTranscriptional analysis of aggressiveness and heterogeneity across grades of astrocytomas.Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma.Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.Modulating roles of amiloride in irradiation-induced antiproliferative effects in glioblastoma multiforme cells involving Akt phosphorylation and the alternative splicing of apoptotic genesInhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisationSignal transduction molecule patterns indicating potential glioblastoma therapy approaches.Modulation of miR-21 signaling by MPS1 in human glioblastomaCirculating biomarker panels for targeted therapy in brain tumors.Nrdp1-mediated ErbB3 degradation inhibits glioma cell migration and invasion by reducing cytoplasmic localization of p27(Kip1).Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclea[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors.Targeted activation of PKA and Epac promotes glioblastoma regression in vitroNetwork analysis of genomic alteration profiles reveals co-altered functional modules and driver genes for glioblastoma.The preliminary radiogenomics association between MR perfusion imaging parameters and genomic biomarkers, and their predictive performance of overall survival in patients with glioblastoma.PHAP1 promotes glioma cell proliferation by regulating the Akt/p27/stathmin pathway.Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment.
P2860
Q33591658-C6B80C17-006E-45F4-9380-62A281D7AA7AQ34300517-FF7C3E63-0D99-4CE7-B89C-1C3C86B91B2FQ35022908-EBBA5FC5-F314-4B5F-95F6-FB740F51C6DFQ35143738-83CB119F-DCCD-412A-B5EE-C3739DB3198CQ35542600-19526ABE-C06C-4101-8BD8-C0FDDD2BCC23Q35913109-1FEEE66B-DBE8-426E-BA53-B497550339CEQ36412836-7617D7AA-C630-4C93-B123-9CA68DEAF704Q37118693-8C27DC56-C573-4A92-98EF-02123E0314A9Q37126130-D9CF861F-CB1B-4114-BCA3-16C370775AC6Q37360227-98134A8C-4BA3-4513-9BCC-D3D5E643C6ECQ37619684-32159C7C-D76D-4FCF-9506-1DC47EFE4414Q38252948-617667C9-476C-444D-8617-2B15473EB1BBQ38862374-5F86B946-84D2-481D-A2C5-2A6AE928AB07Q39022998-9A392E80-C723-47D6-96CA-C7EB5FD7D0DDQ39769284-21623EBA-65CB-4E96-8717-DCF129CD41D4Q41919042-107886E6-B8DE-470F-85A2-FC849CAD94E6Q46690739-F9E6F08A-536C-49FF-BCA4-5B16556FEACEQ48098509-03AD20D2-D4BF-4870-BF49-675B57029FCFQ52581030-EA8B2773-91E9-4964-9FD3-1619AE79F063Q52593633-28992406-E4EE-4CAD-AE69-EF40C58583A6
P2860
The phosphoinositide 3-kinase signaling pathway as a therapeutic target in grade IV brain tumors.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@en
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@nl
type
label
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@en
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@nl
prefLabel
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@en
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@nl
P2093
P1476
The phosphoinositide 3-kinase ...... rget in grade IV brain tumors.
@en
P2093
P304
P356
10.2174/156800911797264743
P577
2011-10-01T00:00:00Z