Lifting the lid on GPCRs: the role of extracellular loops.
about
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptorNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsSingle Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free ReceptorKey interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorAdaptive evolution of the STRA6 genes in mammalianHydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.Chemosensory adaptations of the mountain fly Drosophila nigrosparsa (Insecta: Diptera) through genomics' and structural biology's lenses.Structure-function of the G protein-coupled receptor superfamily.Structure prediction of the second extracellular loop in G-protein-coupled receptorsOn the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation.Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxinG protein-coupled odorant receptors: From sequence to structure.G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactionsInvestigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).Small expression tags enhance bacterial expression of the first three transmembrane segments of the apelin receptor.Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors.Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.The G protein-coupled receptor rhodopsin: a historical perspectiveFrizzled and LRP5/6 receptors for Wnt/β-catenin signalingMolecular Determinants of CGS21680 Binding to the Human Adenosine A2A ReceptorUse of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1Novel insights on thyroid-stimulating hormone receptor signal transduction.Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.The role of the extracellular loops of the CGRP receptor, a family B GPCR.The activation of the CGRP receptor.Revision of the classical dopamine D2 agonist pharmacophore based on an integrated medicinal chemistry, homology modelling and computational docking approach.Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes.G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine.Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells.New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling.Structural insight to mutation effects uncover a common allosteric site in class C GPCRsA structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.
P2860
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P2860
Lifting the lid on GPCRs: the role of extracellular loops.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Lifting the lid on GPCRs: the role of extracellular loops.
@en
Lifting the lid on GPCRs: the role of extracellular loops.
@nl
type
label
Lifting the lid on GPCRs: the role of extracellular loops.
@en
Lifting the lid on GPCRs: the role of extracellular loops.
@nl
prefLabel
Lifting the lid on GPCRs: the role of extracellular loops.
@en
Lifting the lid on GPCRs: the role of extracellular loops.
@nl
P2093
P2860
P50
P1476
Lifting the lid on GPCRs: the role of extracellular loops.
@en
P2093
P2860
P304
P356
10.1111/J.1476-5381.2011.01629.X
P407
P577
2012-03-01T00:00:00Z