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A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal StructuresGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesThe Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased AgonismKey interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorGlucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activationSecond extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.Consequences of splice variation on Secretin family G protein-coupled receptor functionStructural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening.Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT((a)) function.Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryStructural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Receptor activity modifying proteins and their potential as drug targets.Lifting the lid on GPCRs: the role of extracellular loops.RAMPs and CGRP receptors.Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.Allostery and Biased Agonism at Class B G Protein-Coupled Receptors.The complexity of signalling mediated by the glucagon-like peptide-1 receptor.Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.Receptor activity modifying proteins (RAMPs) interact with the VPAC2 receptor and CRF1 receptors and modulate their function.Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions.β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.Structural biology: meet the B family.Prediction of Loops in G Protein-Coupled Receptor Homology Models: Effect of Imprecise Surroundings and Constraints.Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets.What determines the magnitude of cellular response for activation of G protein-coupled receptors?Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.Allosteric modulation of endogenous metabolites as an avenue for drug discovery.Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†Structural basis of Gs and Gi recognition by the human glucagon receptor
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P50
description
hulumtuese
@sq
onderzoeker
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researcher
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հետազոտող
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name
Denise Wootten
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Denise Wootten
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Denise Wootten
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Denise Wootten
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Denise Wootten
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type
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Denise Wootten
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Denise Wootten
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Denise Wootten
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Denise Wootten
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Denise Wootten
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prefLabel
Denise Wootten
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Denise Wootten
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Denise Wootten
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Denise Wootten
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Denise Wootten
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P106
P1153
15066143000
P21
P31
P496
0000-0003-4563-1642