Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
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The reactive metabolite target protein database (TPDB)--a web-accessible resourceProteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures.Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell deathSelective protein arylation and acetaminophen-induced hepatotoxicity.Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions.Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology.Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.Kinetic modeling of nicotine in mainstream cigarette smoking.Tissue acylation by the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane.Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice.Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty?Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages.Role of immune reactions in drug-induced liver injury (DILI).The right compound in the right assay at the right time: an integrated discovery DMPK strategy.Pathogen infection as a possible cause for autoimmune hepatitis.Three common pathways of nephrotoxicity induced by halogenated alkenes.Soft particle analysis of electrokinetics of biological cells and their model systems.Reversibility of covalent electrophile-protein adducts and chemical toxicity.Protein targets of reactive electrophiles in human liver microsomes.The role of metabolic activation in drug toxicity.Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury.Biotransformation and membrane transport in nephrotoxicity.Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase.Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin.Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide- but not from ethylene oxide-induced DNA strand breaks.The role of haptic macrophages in regulation of idiosyncratic drug reactions.Effect of hepatotoxic doses of paracetamol and carbon tetrachloride on the serum and hepatic carboxylesterase activity in mice.Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.Genes encoding the acetaminophen and selenium binding proteins map to mouse chromosome 3.Understanding the cytotoxicity or cytoprotective effects of biological and synthetic quinone derivatives by redox mechanism.
P2860
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P2860
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@en
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@nl
type
label
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@en
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@nl
prefLabel
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@en
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@nl
P1476
Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals.
@en
P2093
P304
P356
10.1146/ANNUREV.PA.30.040190.001125
P577
1990-01-01T00:00:00Z