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Role of endoplasmic reticulum stress in drug-induced toxicityFormation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective EffectsA universal system to select gene-modified hepatocytes in vivoLong Term Influence of Carbon Nanoparticles on Health and Liver Status in RatsQuinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?Lessons from a BACE1 inhibitor trial: off-site but not off base.A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications.Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model.Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays.Latest advances in predicting DILI in human subjects: focus on biomarkers.Practical approaches to resolving reactive metabolite liabilities in early discovery.An overview on the proposed mechanisms of antithyroid drugs-induced liver injury.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results.Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer.Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences.As a painkiller: a review of pre- and postnatal non-steroidal anti-inflammatory drug exposure effects on the nervous systems.Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.Selected scientific topics of the 11th International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labeled Compounds.Xiaoaiping Induces Developmental Toxicity in Zebrafish Embryos Through Activation of ER Stress, Apoptosis and the Wnt Pathway
P2860
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P2860
description
article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Metabolic activation in drug-induced liver injury.
@en
Metabolic activation in drug-induced liver injury.
@nl
type
label
Metabolic activation in drug-induced liver injury.
@en
Metabolic activation in drug-induced liver injury.
@nl
prefLabel
Metabolic activation in drug-induced liver injury.
@en
Metabolic activation in drug-induced liver injury.
@nl
P2093
P2860
P1476
Metabolic activation in drug-induced liver injury.
@en
P2093
Amit S Kalgutkar
Louis Leung
R Scott Obach
P2860
P356
10.3109/03602532.2011.605791
P407
P577
2011-09-23T00:00:00Z