Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
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Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemiaMitochondria, cholesterol and cancer cell metabolismHypoxic control of metastasisHypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and TransactivitySuccinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and EpigeneticsMechanisms of epigenetic regulation of leukemia onset and progressionConnections between TET proteins and aberrant DNA modification in cancerLinking metabolism and epigenetic regulation in development of hepatocellular carcinomaFueling immunity: insights into metabolism and lymphocyte functionKCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacologyLXY6090 - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibitionSTAT3 or USF2 contributes to HIF target gene specificity.Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation.HIFs enhance the transcriptional activation and splicing of adrenomedullin.Prognostic value of isocitrate dehydrogenase mutations in myelodysplastic syndromes: a retrospective cohort study and meta-analysis.Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cellsProgress in aptamer-mediated drug delivery vehicles for cancer targeting and its implications in addressing chemotherapeutic challenges.Hypoxia regulates alternative splicing of HIF and non-HIF target genes.Oncometabolites: linking altered metabolism with cancer.L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.The contributions of HIF-target genes to tumor growth in RCC.TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.Oxygen concentration controls epigenetic effects in models of familial paraganglioma.Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signallingACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.Emerging insights into the molecular and cellular basis of glioblastoma.Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?Spectrum of somatic mitochondrial mutations in five cancersUpstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells.The Mitochondrial Basis of Aging.Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.Bioavailable affinity label for collagen prolyl 4-hydroxylase.In scarcity and abundance: metabolic signals regulating cell growthBRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversibleArginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.Metabolism and epigenetics.STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
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P2860
Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Cancer and altered metabolism: ...... utarate-dependent dioxygenases
@en
Cancer and altered metabolism: ...... tarate-dependent dioxygenases.
@nl
type
label
Cancer and altered metabolism: ...... utarate-dependent dioxygenases
@en
Cancer and altered metabolism: ...... tarate-dependent dioxygenases.
@nl
prefLabel
Cancer and altered metabolism: ...... utarate-dependent dioxygenases
@en
Cancer and altered metabolism: ...... tarate-dependent dioxygenases.
@nl
P2860
P1476
Cancer and altered metabolism: ...... utarate-dependent dioxygenases
@en
P2093
W G Kaelin
P2860
P304
P356
10.1101/SQB.2011.76.010975
P577
2011-11-16T00:00:00Z