Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy.
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Drugging topoisomerases: lessons and challengesAnti-cancer agents in Saudi Arabian herbals revealed by automated high-content imaging.Intramolecular dehydro-Diels-Alder reaction affords selective entry to arylnaphthalene or aryldihydronaphthalene lignansThe anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression.Synthesis of CaCO3 Nanobelts for Drug Delivery in Cancer TherapyDual Inhibitors Against Topoisomerases and Histone DeacetylasesDual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition.Combination of Near Infrared Light-Activated Photodynamic Therapy Mediated by Indocyanine Green with Etoposide to Treat Non-Small-Cell Lung CancerPhytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Boron-Based Drug Design.Review structure- and dynamics-based computational design of anticancer drugs.2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.Topoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium(ii) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives.Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549.Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases.An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3-L1 normal murine cells.Preparation of hierarchical mesoporous CaCO3 by a facile binary solvent approach as anticancer drug carrier for etoposide.Substrate-mediated proton relay mechanism for the religation reaction in topoisomerase II.A selective artificial enzyme inhibitor based on nanoparticle-enzyme interactions and molecular imprinting.The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity.Regioselective Synthesis of Polycyclic and Heptagon-embedded Aromatic Compounds through a Versatile π-Extension of Aryl Halides.Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7.Topoisomerases as anticancer targets.One-pot synthesis of highly substituted polyheteroaromatic compounds by rhodium(III)-catalyzed multiple C-H activation and annulation.Drug-induced conformational population shifts in topoisomerase-DNA ternary complexes.HY-2, a novel DNA topoisomerase II inhibitor, induces G2/M cell cycle arrest in HCT-116 cells.Less toxic zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine ,-dimethylthiosemicarbazone: synthesis, crystal structures, cytotoxicity and investigations of mechanisms of actionPhenazine N,N′-dioxide scaffold as selective hypoxic cytotoxin pharmacophore. Structural modifications looking for further DNA topoisomerase II-inhibition activitynZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα
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P2860
Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
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artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Contemporary challenges in the ...... itors for cancer chemotherapy.
@en
Contemporary challenges in the ...... itors for cancer chemotherapy.
@nl
type
label
Contemporary challenges in the ...... itors for cancer chemotherapy.
@en
Contemporary challenges in the ...... itors for cancer chemotherapy.
@nl
prefLabel
Contemporary challenges in the ...... itors for cancer chemotherapy.
@en
Contemporary challenges in the ...... itors for cancer chemotherapy.
@nl
P356
P1433
P1476
Contemporary challenges in the ...... itors for cancer chemotherapy.
@en
P2093
Christian Bailly
P304
P356
10.1021/CR200325F
P577
2012-03-08T00:00:00Z