Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs. - Wikidata - wikimedia - TriplyDB

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

http://www.wikidata.org/entity/Q37998132

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Synthesis of nucleoside phosphate and phosphonate prodrugs Prodrugs of phosphonates and phosphates: crossing the membrane barrier Scaffold hopping with virtual screening from IP3 to a drug-like partial agonist of the inositol trisphosphate receptor.Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.2-Methoxypyridine as Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability and NMR Structural Studies.Flex-nucleoside analogues - Novel therapeutics against filoviruses.Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.The discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C.Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.Synthesis of phosphoramidate prodrugs: ProTide approach.Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents.A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.

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Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

http://www.wikidata.org/entity/Q37998132

description

article científic

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article scientifique

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articol științific

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articolo scientifico

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artigo científico

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artigo científico

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artigo científico

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artikel ilmiah

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artikull shkencor

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artículo científico

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name

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@en

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@nl

type

label

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@en

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@nl

prefLabel

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@en

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@nl

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Future Medicinal Chemistry

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Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

@en

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Christopher McGuigan

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Karolina Madela

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P2860

Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977

Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

Expert opinion on the treatment of patients with chronic hepatitis C

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets

Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha

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625-650

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scholarly article

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10.4155/FMC.12.10

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5

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4

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2012-04-01T00:00:00Z

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22458682

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