about
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseNovel autophosphorylation sites of Src family kinases regulate kinase activity and SH2 domain-binding capacityAcidic priming enhances metastatic potential of cancer cells.Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL KinaseSRChing for the substrates of Src.Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial InfectionProfiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.The importance of Src signaling in sarcoma.Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice.High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer.Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis.Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the keyA review of targeted therapies evaluated by the pediatric preclinical testing program for osteosarcoma.MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib.Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin.MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cellsTyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders.Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target?Novel approaches to the development of tyrosine kinase inhibitors and their role in the fight against cancer.Src family kinases: at the forefront of platelet activationMolecular Pathways: New Signaling Considerations When Targeting Cytoskeletal Balance to Reduce Tumor Growth.Integrin signalling regulates YAP and TAZ to control skin homeostasis.Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.Src family kinases in chronic kidney disease.P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade.Drugs for solid cancer: the productivity crisis prompts a rethink.Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis.Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.Targeting Src attenuates peritoneal fibrosis and inhibits the epithelial to mesenchymal transition.The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis.Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation.Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Src kinase inhibitors: promising cancer therapeutics?
@en
Src kinase inhibitors: promising cancer therapeutics?
@nl
type
label
Src kinase inhibitors: promising cancer therapeutics?
@en
Src kinase inhibitors: promising cancer therapeutics?
@nl
prefLabel
Src kinase inhibitors: promising cancer therapeutics?
@en
Src kinase inhibitors: promising cancer therapeutics?
@nl
P1476
Src kinase inhibitors: promising cancer therapeutics?
@en
P2093
Helen Creedon
Valerie G Brunton
P304
P356
10.1615/CRITREVONCOG.V17.I2.20
P407
P577
2012-01-01T00:00:00Z