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Stress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cellsThe BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.Upregulation of glycolytic enzymes, mitochondrial dysfunction and increased cytotoxicity in glial cells treated with Alzheimer's disease plasma.Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells.Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1(G93A) mouse model of Amyotrophic Lateral Sclerosis.NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.Differential molecular chaperone response associated with various mouse adapted scrapie strains.Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.ESCRT regulates surface expression of the Kir2.1 potassium channel.DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.Stress proteins in aging and life span.Protein recycling pathways in neurodegenerative diseases.Druggable sensors of the unfolded protein response.The role of endoplasmic reticulum stress in human pathology.Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).Therapeutic Strategies for Restoring Tau Homeostasis.Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Misfolding, Aggregation, and Mutation-dependent Neurodegeneration by Dysfunction of the Autophagic Flux.Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis.A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation.Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival.ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.Nondamaging Retinal Laser Therapy: Rationale and Applications to the Macula.Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases.Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Protein quality control in neurodegenerative disease.
@en
type
label
Protein quality control in neurodegenerative disease.
@en
prefLabel
Protein quality control in neurodegenerative disease.
@en
P1476
Protein quality control in neurodegenerative disease.
@en
P2093
Jason E Gestwicki
P304
P356
10.1016/B978-0-12-385883-2.00003-5
P577
2012-01-01T00:00:00Z