Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.
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Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based TherapiesThe Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic NanomachinesMitochondrial targets for pharmacological intervention in human diseaseCombotherapy and current concepts as well as future strategies for the treatment of Alzheimer's diseaseKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationTranslocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcuminCurrent advances in systems and integrative biologyKnowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer's disease.Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease.Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model.Mechanistic Insight of Bivalent Compound 21MO as Potential Neuroprotectant for Alzheimer's DiseaseMitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model.Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function.APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones.Mitochondrial metals as a potential therapeutic target in neurodegeneration.Combining two repurposed drugs as a promising approach for Alzheimer's disease therapyMitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease.Oxidative Stress and Aberrant Cell Cycle in Alzheimer's Disease Lymphocytes: Diagnostic Prospects.Knowledge-Based Compact Disease Models: A Rapid Path from High-Throughput Data to Understanding Causative Mechanisms for a Complex Disease.Curcumin, inflammation, and chronic diseases: how are they linked?The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity.A Mitochondrial Role of SV2a Protein in Aging and Alzheimer's Disease: Studies with Levetiracetam.Bivalent Compound 17MN Exerts Neuroprotection through Interaction at Multiple Sites in a Cellular Model of Alzheimer's DiseaseRCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer's disease.Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice.MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease.¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues.Development and Characterization of Methylene Blue Oleate Salt-Loaded Polymeric Nanoparticles and their Potential Application as a Treatment for Glioblastoma.Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects.Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer's Disease Mouse Model.Effects of long-term treatment with quercetin on cognition and mitochondrial function in a mouse model of Alzheimer's disease.Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease.Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice.Effects of Grape Skin Extract on Age-Related Mitochondrial Dysfunction, Memory and Life Span in C57BL/6J Mice.TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway.Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components.
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Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.
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type
label
Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.
@en
prefLabel
Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.
@en
P2093
P2860
P1476
Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.
@en
P2093
Christopher Kurz
Gunter P Eckert
Janett Eckmann
Kathrin Renner
Kristina Leuner
Reham M Abdel-Kader
Schamim H Eckert
Stephanie Hagl
Walter E Muller
P2860
P2888
P304
P356
10.1007/S12035-012-8271-Z
P577
2012-05-03T00:00:00Z
P6179
1031315110