Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating "clinical proof-of-concept" for AAV-neurturin (CERE-120) in Parkinson's disease.
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Parkinson's disease gene therapy: success by design meets failure by efficacyTreating Parkinson's disease in the 21st century: can stem cell transplantation compete?Systemic gene delivery to the central nervous system using Adeno-associated virus.Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses.Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients.A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives.Adeno-associated virus vectors and neurological gene therapy.Beyond traditional pharmacology: new tools and approaches.Viral vector delivery of neurotrophic factors for Parkinson's disease therapy.Trophic factors for Parkinson's disease: To live or let die.Perspective on the Road toward Gene Therapy for Parkinson's Disease.Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson's disease.Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease.In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System.Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.Bioactivity-guided fractionation identifies amygdalin as a potent neurotrophic agent from herbal medicine Semen Persicae extractModulation of Abnormal Metabolic Brain Networks by Experimental Therapies in a Nonhuman Primate Model of Parkinson Disease: An Application to Human Retinal Pigment Epithelial Cell Implantation.Gene therapy for Parkinson's disease: a decade of progress supported by posthumous contributions from volunteer subjects.Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain.
P2860
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P2860
Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating "clinical proof-of-concept" for AAV-neurturin (CERE-120) in Parkinson's disease.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Advancing neurotrophic factors ...... E-120) in Parkinson's disease.
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type
label
Advancing neurotrophic factors ...... E-120) in Parkinson's disease.
@en
prefLabel
Advancing neurotrophic factors ...... E-120) in Parkinson's disease.
@en
P2093
P1476
Advancing neurotrophic factors ...... E-120) in Parkinson's disease.
@en
P2093
Brian R Kruegel
Christopher D Herzog
Jeffrey M Ostrove
Lamar Brown
Raymond T Bartus
Tiffany L Baumann
P356
10.1016/J.NEUROBIOLAGING.2012.07.018
P577
2012-08-24T00:00:00Z