Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.
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Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesTangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing ProblemLysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosisThe role of extracellular vesicles in the progression of neurodegenerative disease and cancerIdentification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics.Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis.Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients.Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer's Disease PathologyADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapySorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Biology and biogenesis of shed microvesicles.Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease.BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases.Dysregulation of Rab5-Mediated Endocytic Pathways in Alzheimer's Disease.
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P2860
Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.
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Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.
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prefLabel
Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.
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P2860
P356
P1476
Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.
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P2093
Jeff Kuret
Kristen E Funk
P2860
P304
P356
10.1155/2012/752894
P577
2012-08-30T00:00:00Z