Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.
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TFEB at a glanceFisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factorsmTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseasesThe endocytic pathway in microglia during health, aging and Alzheimer's disease.Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis modelDeacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microgliaSalvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells.The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB PerspectiveThe lysosome as a command-and-control center for cellular metabolism.TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin.Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells.Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Astrocytes and synaptic plasticity in health and disease.Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.Targeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain.Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux.NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.Identification of Sidt2 as a lysosomal cation-conducting protein.Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation.Using Drosophila Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer's Disease.Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease.Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic ReviewPossible Clues for Brain Energy Translation via Endolysosomal Trafficking of APP-CTFs in Alzheimer's DiseaseTFEB, a potential therapeutic target for osteoarthritis via autophagy regulationEarly lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
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Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
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name
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@ast
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@en
type
label
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@ast
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@en
prefLabel
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@ast
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@en
P2093
P2860
P50
P1476
Neuronal-Targeted TFEB Acceler ...... d Amyloid Plaque Pathogenesis.
@en
P2093
Ernesto Gonzales
Haiyan Liu
John R Cirrito
Qingli Xiao
Ronaldo Perez
P2860
P304
12137-12151
P356
10.1523/JNEUROSCI.0705-15.2015
P407
P577
2015-09-01T00:00:00Z