Novel M(1) allosteric ligands: a patent review.

Novel M(1) allosteric ligands: a patent review.

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http://www.wikidata.org/entity/Q38054855
Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseMechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsWhy an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine.Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophreniaEmploying novel animal models in the design of clinically efficacious GPCR ligands.Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.Pyrrolopyridine or Pyrazolopyridine Derivatives.Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration
P2860

Novel M(1) allosteric ligands: a patent review.

Item
http://www.wikidata.org/entity/Q38054855
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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Novel M(1) allosteric ligands: a patent review.
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Novel M(1) allosteric ligands: a patent review.
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Novel M(1) allosteric ligands: a patent review.
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Novel M(1) allosteric ligands: a patent review.
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P2860
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10.1517/13543776.2012.731395
P407
P433
P478
P577
P698