Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

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Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.

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Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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Further optimization of the M1 ...... with improved CNS penetration

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Further optimization of the M1 ...... with improved CNS penetration

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Further optimization of the M1 ...... with improved CNS penetration

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Further optimization of the M1 ...... with improved CNS penetration

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P2093

Anna L Blobaum

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Hykeyung P Cho

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Jeffrey J Adams

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Joseph D Panarese

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Kellie D Nance

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Pedro M Garcia-Barrantes

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Ryan D Morrison

http://www.w3.org/2001/XMLSchema#string

Shaun R Stauffer

http://www.w3.org/2001/XMLSchema#string

Sichen Chang

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P2860

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

The antipsychotic potential of muscarinic allosteric modulation

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.

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3822-3825

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scholarly article

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10.1016/J.BMCL.2016.04.083

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English

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Colleen M. Niswender

Craig W. Lindsley

P Jeffrey Conn

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2016-04-29T00:00:00Z

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27173801

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5082649

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Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

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P2860

P2860

Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

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