Interaction between natural compounds and human topoisomerase I.
about
Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantAdvantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein-DNA binding siteB-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity.A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cellsMolecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system.Inhibition of DNA-Topoisomerase I by Acylated Triterpene Saponins from Pittosporum angustifolium Lodd.Role of the protein in the DNA sequence specificity of the cleavage site stabilized by the camptothecin topoisomerase IB inhibitor: a metadynamics study.Supplementation with Achyrocline satureioides Inflorescence Extracts to Pregnant and Breastfeeding Rats Induces Tissue-Specific Changes in Enzymatic Activity and Lower Neonatal Survival.
P2860
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P2860
Interaction between natural compounds and human topoisomerase I.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Interaction between natural compounds and human topoisomerase I.
@en
type
label
Interaction between natural compounds and human topoisomerase I.
@en
prefLabel
Interaction between natural compounds and human topoisomerase I.
@en
P50
P356
P1433
P1476
Interaction between natural compounds and human topoisomerase I
@en
P2093
Paola Fiorani
Silvia Castelli
P304
P356
10.1515/HSZ-2012-0240
P577
2012-11-01T00:00:00Z