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Single mutations at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutaseActive-site copper and zinc ions modulate the quaternary structure of prokaryotic Cu,Zn superoxide dismutaseReptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolutionEvolutionary constraints for dimer formation in prokaryotic Cu,Zn superoxide dismutaseStructural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studiesSampling the structure of the noncanonical lin-4:lin-14 microRNA:mRNA complex by molecular dynamics simulationsStructural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complexDevelopment of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisonsBinding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interactionSolvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probesReplacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantMolecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation.Modelling the three-dimensional structure and the electrostatic potential field of two Cu,Zn superoxide dismutase variants from tomato leaves.Modelling the three-dimensional structure and electrostatic potential field of the two Cu,Zn superoxide dismutase variants from Xenopus laevis.Experimental and simulative dissociation of dimeric Cu,Zn superoxide dismutase doubly mutated at the intersubunit surfaceMolecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant.MD simulations of papillomavirus DNA-E2 protein complexes hints at a protein structural code for DNA deformation.Effects of laser radiation on Rhus vernicifera laccase, Type 2 Cu-depleted laccase, and stellacyanin.A resonance Raman study of native stellacyanin and its Ni(II) derivative. On the origin of the 450-nm electronic absorption.Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity.Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist.Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein-DNA binding siteIn vitro analysis of pyrogenicity and cytotoxicity profiles of flex sensors to be used to sense human joint posturesMutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification.Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads.The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant.Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum.Molecular Characterization of the First Ebola Virus Isolated in Italy, from a Health Care Worker Repatriated from Sierra LeoneMolecular Signature of the Ebola Virus Associated with the Fishermen Community Outbreak in Aberdeen, Sierra Leone, in February 2015Molecular mechanism of statin-mediated LOX-1 inhibition.Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.Interaction between natural compounds and human topoisomerase I.Dynamic changes in gene expression profiles of 22q11 and related orthologous genes during mouse development.Single mutation induces a metal-dependent subunit association in dimeric Cu,Zn superoxide dismutase.Effect of oxindolimine copper(II) and zinc(II) complexes on human topoisomerase I activity.Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.
P50
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P50
description
researcher
@en
wetenschapper
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հետազոտող
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name
Alessandro Desideri
@ast
Alessandro Desideri
@en
Alessandro Desideri
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Alessandro Desideri
@nl
type
label
Alessandro Desideri
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Alessandro Desideri
@en
Alessandro Desideri
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Alessandro Desideri
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prefLabel
Alessandro Desideri
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Alessandro Desideri
@en
Alessandro Desideri
@es
Alessandro Desideri
@nl
P106
P21
P31
P496
0000-0003-1541-4217