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Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseTowards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in MacaqueSynaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorderVariants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample.Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2α-ATF4 pathway.Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson diseaseEpicatechin Reduces Striatal MPP⁺-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity.Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T MutantLeucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway.Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.Targeting the chameleon: a focused look at α-synuclein and its roles in neurodegeneration.Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease.Silencing of SIAH1 in SH-SY5Y affects α-synuclein degradation pathway.Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders.Transcriptome Profile Changes in Mice with MPTP-Induced Early Stages of Parkinson's Disease.Ceftriaxone blocks the polymerization of α-synuclein and exerts neuroprotective effects in vitroPrenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation.Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP.Understanding the lived experiences of Parkinson's disease and deep brain stimulation (DBS) through occupational changes.Pulsed HDX Illuminates the Aggregation Kinetics of Alpha-Synuclein, the Causative Agent for Parkinson's Disease.Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson's disease.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
The central theme of Parkinson's disease: α-synuclein.
@en
type
label
The central theme of Parkinson's disease: α-synuclein.
@en
prefLabel
The central theme of Parkinson's disease: α-synuclein.
@en
P2860
P1476
The central theme of Parkinson's disease: α-synuclein.
@en
P2093
A Nazli Başak
Mehmet Ozansoy
P2860
P2888
P304
P356
10.1007/S12035-012-8369-3
P577
2012-11-23T00:00:00Z
P6179
1012508788