Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.
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Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevanceEvaluation of rhesus monkey and guinea pig hepatic cytosol fractions as models for human aldehyde oxidase.Why do most human liver cytosol preparations lack xanthine oxidase activity?Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.The role of drug metabolizing enzymes in clearance.A simple litmus test for aldehyde oxidase metabolism of heteroarenes.Structure and function of mammalian aldehyde oxidases.Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.Modern advances in heterocyclic chemistry in drug discovery.Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery.ADME SARfari: comparative genomics of drug metabolizing systems.Structure-metabolism relationships in human-AOX: Chemical insights from a large database of aza-aromatic and amide compounds.Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane.A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry.Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human.Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp.An industry perspective on tiered approach to the investigation of metabolites in drug development.Metabolism of xenobiotics by aldehyde oxidase.
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P2860
Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.
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label
Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.
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prefLabel
Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.
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P2093
P2860
P1476
Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.
@en
P2093
Deepak Dalvie
James Matthew Hutzler
Michael A Zientek
Ronald Scott Obach
P2860
P304
P356
10.1517/17425255.2013.738668
P407
P577
2012-12-12T00:00:00Z