Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.
about
Pregnane X receptor and drug-induced liver injury.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoSmall-molecule modulators of PXR and CAR.Opportunities and challenges in using human hepatocytes in cytochromes P450 induction assays.Evaluation of a novel PXR-knockout in HepaRG™ cells.Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug-drug Interactions in Adult Life.SPA70 is a potent antagonist of human pregnane X receptor.Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.
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P2860
Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Evaluation of pregnane X recep ...... eractions in drug development.
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type
label
Evaluation of pregnane X recep ...... eractions in drug development.
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prefLabel
Evaluation of pregnane X recep ...... eractions in drug development.
@en
P2860
P1476
Evaluation of pregnane X recep ...... eractions in drug development.
@en
P2093
Michael W Sinz
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P356
10.3109/03602532.2012.743560
P407
P577
2013-02-01T00:00:00Z