Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Functional roles of protein nitration in acute and chronic liver diseasesC-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.Mechanisms of aging-related proteinopathies in Caenorhabditis elegansToxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synucleinα-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotectionEndoplasmic reticulum stress and inflammation in the central nervous systemThe N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson diseaseIntracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sitesMitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stressMetal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach.Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies.Neuropathology of α-synuclein propagation and braak hypothesis.Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples.Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies.Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.The Proteasome Inhibition Model of Parkinson's Disease.Identification of novel biomarkers for Parkinson's disease by metabolomic technologies.Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's diseaseIsogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes.Progress toward an integrated understanding of Parkinson's disease.Reactivity of copper-α-synuclein peptide complexes relevant to Parkinson's disease.α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease.Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson's disease.Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone.GYY4137, an H2S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson's Disease.Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein.Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging.Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model
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Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Oxidative and nitrative alpha- ...... ventions in synucleinopathies.
@en
type
label
Oxidative and nitrative alpha- ...... ventions in synucleinopathies.
@en
prefLabel
Oxidative and nitrative alpha- ...... ventions in synucleinopathies.
@en
P2093
P2860
P50
P356
P1476
Oxidative and nitrative alpha- ...... rventions in synucleinopathies
@en
P2093
Christiaan Karreman
Hanne R Gerding
Hilal A Lashuel
Malte Drescher
Stefan Schildknecht
P2860
P304
P356
10.1111/JNC.12226
P407
P577
2013-03-19T00:00:00Z