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Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.Lysosomal degradation of alpha-synuclein in vivo.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injuryEnhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections.Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.Mesenchymal stromal SB623 cell implantation mitigates nigrostriatal dopaminergic damage in a mouse model of Parkinson's disease.Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.Function and developmental origin of a mesocortical inhibitory circuit.Restorative effects of platelet derived growth factor-BB in rodent models of Parkinson's disease.Evidence of oxidative stress in young and aged DJ-1-deficient mice.Neurodegeneration by activation of the microglial complement-phagosome pathway.In vivo models of alpha-synuclein transmission and propagation.Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration.Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age.Phosphorylation of Parkin at serine 65 is essential for its activationInduction of cell damage by menadione and benzo(a)-pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblastsOxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transferActivation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.
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description
investigador
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researcher
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wetenschapper
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name
Donato A Di Monte
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Donato A Di Monte
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type
label
Donato A Di Monte
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Donato A Di Monte
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prefLabel
Donato A Di Monte
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Donato A Di Monte
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P31
P496
0000-0002-8296-836X