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Advances in mechanisms of anti-oxidationNrf2 as a master regulator of tissue damage control and disease tolerance to infectionThe spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergeticsEndogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic DerivativesAntioxidant Properties of Whole Body Periodic Acceleration (pGz)Adaptive regulation of the brain's antioxidant defences by neurons and astrocytesQuercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development StrategyNrf2 Is an Attractive Therapeutic Target for Retinal DiseasesDiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsMechanisms of Action of Antiseizure Drugs and the Ketogenic DietMetallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosisCoffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cellsRole of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in miceIsolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in UbiquitinationAlisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cellsNuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activationProteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approachThe complexity of the Nrf2 pathway: beyond the antioxidant responsePro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling patStabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathyThe Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UVChemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoidsCytoprotection "gone astray": Nrf2 and its role in cancerLack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled TrialOxidative Stress and Response to Thymidylate Synthase-Targeted AntimetabolitesNeuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcriptionThe clinical potential of influencing Nrf2 signaling in degenerative and immunological disordersSystemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cellsA novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune systemHDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agentsCytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell LineModulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseasesThe potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult MiceProtein redox modification as a cellular defense mechanism against tissue ischemic injury.NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis.
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Toward clinical application of the Keap1-Nrf2 pathway.
@en
type
label
Toward clinical application of the Keap1-Nrf2 pathway.
@en
prefLabel
Toward clinical application of the Keap1-Nrf2 pathway.
@en
P2093
P1476
Toward clinical application of the Keap1-Nrf2 pathway.
@en
P2093
Hozumi Motohashi
Masayuki Yamamoto
Takafumi Suzuki
P304
P356
10.1016/J.TIPS.2013.04.005
P577
2013-05-09T00:00:00Z