The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis.
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Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequenceActivated neu oncogene sequences in primary tumors of the peripheral nervous system induced in rats by transplacental exposure to ethylnitrosourea5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2).MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.In vivo studies of DnaA binding to the origin of replication of Escherichia coli.7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection5-methylcytosine in RNA: detection, enzymatic formation and biological functions.DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNAChemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cellsIn vivo formation and persistence of modified nucleosides resulting from alkylating agents.Cell specificity in DNA binding and repair of chemical carcinogens.Effects of alkylation of phosphodiesters and of bases of infectivity and stability of tobacco mosaic virus RNA.Identification of the 5' end of Rous sarcoma virus RNATwo rotameric forms of open ring 7-methylguanine are present in alkylated polynucleotidesRelease of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coliHuman lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladeninesSpecific recognition of apurinic sites in DNA by a tryptophan-containing peptide.7-Methylguanine in poly(dG-dC).poly(dG-dC) facilitates z-DNA formation.Mutational and in vivo methylation analysis of F-factor PifC protein binding to the pif operator and the region containing the primary origin of mini-F replication.Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased GenesA theoretical evaluation of the effect of netropsin binding on the reactivity of DNA towards alkylating agents.Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.Synthesis and coding properties of dinucleoside diphosphates containing alky pyrimidines which are formed by the action of carcinogens on nucleic acids.Fluoride ion catalyzed alkylation of nucleic acid derivatives using trialkyl phosphates, dialkyl sulfates and alkyl methanesulfonatesEvidence for removal at different rates of O-ethyl pyrimidines and ethylphosphotriesters in two human fibroblast cell lines.The molecular electrostatic potential of the B-DNA helix. VI. The regions of the base pairs in poly (dG.dC) and poly (dA.dT).Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.Modifications of guanine bases during oligonucleotide synthesis.Bacillus subtilis alkA gene encoding inducible 3-methyladenine DNA glycosylase is adjacent to the ada operonRepair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage by ABC excinuclease.Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression.Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.DNA polymerase III requirement for repair of DNA damage caused by methyl methanesulfonate and hydrogen peroxide.Covalent adducts of DNA and the nonprotein chromophore of neocarzinostatin contain a modified deoxyribose.Differences in temporal aspects of mutagenesis and cytotoxicity in Chinese hamster cells treated with methylating agents and thymidineBacillus subtilis mutants deficient in the adaptive response to simple alkylating agents.Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitorChemical methylation of RNA and DNA viral genomes as a probe of in situ structureAlterations of gene structure in ethyl methane sulfonate-induced mutants of mammalian cells.
P2860
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P2860
The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The chemical effects of nuclei ...... utagenesis and carcinogenesis.
@en
type
label
The chemical effects of nuclei ...... utagenesis and carcinogenesis.
@en
prefLabel
The chemical effects of nuclei ...... utagenesis and carcinogenesis.
@en
P1476
The chemical effects of nuclei ...... utagenesis and carcinogenesis.
@en
P2093
P304
P577
1975-01-01T00:00:00Z