DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
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Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequenceSite-Specific Stabilization of DNA by a Tethered Major Groove Amine, 7-Aminomethyl-7-deaza-2′-deoxyguanosineDNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugateSulphur mustards inhibit binding of transcription factor AP2 in vitroCharacterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.A study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine base pairing in DNA.Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts.Formation of cis-diamminedichloroplatinum(II) 1,2-intrastrand cross-links on DNA is flanking-sequence independentCovalent cross-linking of duplex DNA using 4-thio-2'-deoxyuridine as a readily modifiable platform for introduction of reactive functionality into oligonucleotidesThe 5'-GNC site for DNA interstrand cross-linking is conserved for diepoxybutane stereoisomersThiol-activated DNA damage by α-bromo-2-cyclopentenone.O6-methylguanine inhibits the binding of transcription factors to DNA.Nearest neighbor effects on carcinogen binding to guanine runs in DNADNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra.Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor.Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9A review of the role of the sequence-dependent electrostatic landscape in DNA alkylation patterns.Target-directed catalytic metallodrugs.DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells.Affinity purification and characterization of human O6-alkylguanine-DNA alkyltransferase complexed with BCNU-treated, synthetic oligonucleotide.Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand.The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.DNA sequence specificity of antitumor agents. Oncogenes as possible targets for cancer therapy.Backbone and benzoyl mustard carrying moiety modifies DNA interactions of distamycin analogues.Protein-DNA interactions in the human beta-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards.Nitrogen mustard inhibits transcription and translation in a cell free system.Molecular basis of nitrogen mustard effects on transcription processes: role of depurination.DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymeraseIntragenomic heterogeneity of DNA damage formation and repair: a review of cellular responses to covalent drug DNA interaction.Perspectives in the field of drug metabolism.Alpha-bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity.Nearest neighbor affects G:C to A:T transitions induced by alkylating agentsDNA interstrand crosslinking and sequence selectivity of dimethanesulphonates.Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit.Structural characterization of melphalan modified 2'-oligodeoxynucleotides by miniaturized LC-ES MS/MS.Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications.Molecular dynamics simulations of chlorambucil/DNA adducts. A structural basis for the 5'-GNC interstrand DNA crosslink formed by nitrogen mustards.
P2860
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P2860
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
description
1986 nî lūn-bûn
@nan
1986 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@ast
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@en
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@nl
type
label
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@ast
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@en
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@nl
prefLabel
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@ast
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@en
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@nl
P2093
P2860
P356
P1476
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
@en
P2093
P2860
P304
P356
10.1093/NAR/14.7.2971
P407
P577
1986-04-01T00:00:00Z