USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.
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DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsSynthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents.Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities.A novel role for the deubiquitinase USP1 in the control of centrosome duplication.CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.Cell death and deubiquitinases: perspectives in cancer.The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.Chemical and semisynthetic approaches to study and target deubiquitinases.The role of USP1 autocleavage in DNA interstrand crosslink repair.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.Harnessing the oxidation susceptibility of deubiquitinases for inhibition with small molecules.Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro.Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.MicroRNA-192-5p suppresses the initiation and progression of osteosarcoma by targeting USP1.Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy
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USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artículo científico
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USP1 deubiquitinase: cellular ...... l as target in cancer therapy.
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type
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USP1 deubiquitinase: cellular ...... l as target in cancer therapy.
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USP1 deubiquitinase: cellular ...... l as target in cancer therapy.
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USP1 deubiquitinase: cellular ...... al as target in cancer therapy
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P2093
Godefridus J Peters
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P2888
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10.1186/1476-4598-12-91
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2013-08-10T00:00:00Z
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P6179
1035355318