Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspective.
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Analogues of luteinizing hormone-releasing hormone containing cytotoxic groupsHuman GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neuronsAmyloid as a depot for the formulation of long-acting drugsHormonesProbing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug developmentThe low-energy conformations of gonadotropin-releasing hormone in aqueous solution.Highly potent antagonists of luteinizing hormone-releasing hormone free of edematogenic effects.Protective effects of analogs of luteinizing hormone-releasing hormone against chemotherapy-induced testicular damage in rats.Evaluation of luteinizing hormone-releasing hormone antagonistic activity in vitro.Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling.Antide and related antagonists of luteinizing hormone release with long action and oral activity.Prolonged inhibition of luteinizing hormone and testosterone levels in male rats with the luteinizing hormone-releasing hormone antagonist SB-75.Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factorsLH-RH analogues: I. Their impact on reproductive medicine.Embryo implantation and GnRH antagonists: embryo implantation: the Rubicon for GnRH antagonists.Embryo implantation and GnRH antagonists: ovarian actions of GnRH antagonists.Highly potent metallopeptide analogues of luteinizing hormone-releasing hormone.Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.Protective effects of analogs of luteinizing hormone-releasing hormone against x-radiation-induced testicular damage in ratsAssessment of the luteal phase in stimulated and substituted cycles.Effect of azaline B on follicular development and functions in the hamster.Mast cells with gonadotropin-releasing hormone-like immunoreactivity in the brain of doves.Low energy conformations for gonadotropin-releasing hormone with D- and L-amino acid substitutions for Gly 6: possible receptor-bound conformations.Decreased release of gonadotropin-releasing hormone during the preovulatory midcycle luteinizing hormone surge in normal women.The effect of GnRH analogues for pituitary suppression on ovarian response in repeated ovarian stimulation cyclesBenign prostatic hyperplasia: an insight into current investigational medical therapies.Abarelix for injectable suspension: first-in-class gonadotropin-releasing hormone antagonist for prostate cancer.Characterization of 12 GnRH peptide agonists - a kinetic perspectiveDevelopment of methods for purification of membrane associated gonadotropin-releasing hormone binding proteins.Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives.Advances in the development of hormonal modulators for the treatment of benign prostatic hyperplasia.GnRH analogues in the prevention of ovarian hyperstimulation syndromeIterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II.Gonadotropin-releasing hormone in the ovary.Short-chain analogs of luteinizing hormone-releasing hormone containing cytotoxic moieties.A convenient approach to synthesizing peptide C-terminal N-alkyl amides.Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevanceDown-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.Betidamino acids: versatile and constrained scaffolds for drug discovery.
P2860
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P2860
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspective.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Gonadotropin-releasing hormone ...... ts: rationale and perspective.
@en
type
label
Gonadotropin-releasing hormone ...... ts: rationale and perspective.
@en
prefLabel
Gonadotropin-releasing hormone ...... ts: rationale and perspective.
@en
P356
P1433
P1476
Gonadotropin-releasing hormone ...... ts: rationale and perspective.
@en
P2093
P356
10.1210/EDRV-7-1-44
P577
1986-02-01T00:00:00Z