Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.
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Value of monitoring Nrf2 activity for the detection of chemical and oxidative stressCellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour.Advances in Engineered Liver Models for Investigating Drug-Induced Liver InjuryCell-Based Assay Design for High-Content Screening of Drug CandidatesStem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injuryContinuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement.The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding.Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial CellsHigh-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities."Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling.Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.Highlight report: 'Big data in the 3R's: outlook and recommendations', a roundtable summary.Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.
P2860
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P2860
Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Quantitative high content imag ...... or chemical safety assessment.
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type
label
Quantitative high content imag ...... or chemical safety assessment.
@en
prefLabel
Quantitative high content imag ...... or chemical safety assessment.
@en
P2093
P50
P356
P1476
Quantitative high content imag ...... or chemical safety assessment.
@en
P2093
Bob van de Water
Bram Herpers
Erik Danen
Giel Hendriks
Marije Niemeijer
Steven Hiemstra
Steven Wink
Suzanna Huppelschoten
P304
P356
10.1021/TX4004038
P577
2014-02-05T00:00:00Z